Finkel Lab
Toren Finkel, MD, PhD
G. Nicholas Beckwith III and Dorothy B. Beckwith Endowed Chair of Translational Medicine Distinguished Professor of Medicine
Finkel Lab
Lab Focus
What question I’d like to answer
Faculty Bio
Selected Publications
Tan JX, Finkel T. A phosphoinositide signalling pathway mediates rapid lysosomal repair. Nature. 2022 Sep;609(7928):815-821. doi: 10.1038/s41586-022-05164-4. Epub 2022 Sep 7. PMID: 36071159; PMCID: PMC9450835.
Torisu T, Torisu K, Lee IH, Liu J, Malide D, Combs CA, Wu XS, Rovira II, Fergusson MM, Weigert R, Connelly PS, Daniels MP, Komatsu M, Cao L, Finkel T. Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. Nat Med. 2013 Oct;19(10):1281-7. doi: 10.1038/nm.3288. Epub 2013 Sep 22. PMID: 24056772; PMCID: PMC3795899.
Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, Xu XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature. 2009 May 21;459(7245):387-392. doi: 10.1038/nature08040. Epub 2009 Apr 29. PMID: 19404261; PMCID: PMC4721521.
Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003 Feb 13;348(7):593-600. doi: 10.1056/NEJMoa022287. PMID: 12584367.
Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science. 1995 Oct 13;270(5234):296-9. doi: 10.1126/science.270.5234.296. PMID: 7569979.
Current Lab Members
Jie Liu PhD – Research Associate Professor
Anita Saraf MD/PhD – Assistant Professor of Medicine
Travis Lear PhD – Postdoctoral Research Fellow
Shohini Ghosh-Choudhary – MD/PhD student
Yu-Wei (Winnie) Cheng – Graduate Student