Cores and Centers
The Metabolism Core of the Aging Institute is managed by the Metabolism Unit in the Center for Metabolism and Mitochondrial Medicine (C3M). The mission of Metabolism Unit is to make available platform technologies, training, and study design and data analysis expertise for in vivo, ex vivo, and in vitro metabolic studies in rodent and cell culture models. The expertise of the unit extends from assessment of metabolic flux, energy expenditure, body composition, insulin sensitivity, exercise capacity, and insulin signaling in the whole animal, to the performance of metabolic, biochemical, and molecular studies in primary and immortal cell culture models of relevance to metabolic diseases.
Preclinical Phenotyping Core (PPC)
The purpose of the Preclinical Phenotyping Core (PPC) is to facilitate characterization of behavioral phenotypes of mouse and rat models studied by investigators throughout the University of Pittsburgh and its affiliated centers, institutes, and hospitals.
Small Animal Hemodynamic Core
The Small Animal Hemodynamic Core specializes in acquisition and analysis of hemodynamic data obtained during survival and terminal studies of rat and murine models. Our team consists of surgeons, bioengineers, and technicians who have extensive experience with the design, implementation, analysis, and reporting of such studies.
Small Molecule Therapeutics Center
The Center for Small Molecule Therapeutics was established in 2015 to increase the scientific understanding and collaborative efforts on developing small molecules that target various pulmonary diseases including ARDS, Asthma, IPF, COPD, Transplant rejection, etc. The mission of the SMTC is to provide our expertise in protein modeling, target validation, small molecule screening, “hits” identification and optimization, in vitro ADME and referrals for additional medicinal or synthetic chemists to the appropriate facilities within PACCM and the Department of Medicine. The center provides an excellent platform for faculty collaboration which hopefully can lead to novel treatments for patients with pulmonary diseases.
Acute Lung Injury Center of Excellence
The Acute Lung Injury Center of Excellence is focused on understanding fundamental mechanisms of lung injury and repair, and integrating findings in basic biology with clinical medicine. The program utilizes advanced tools in molecular, biochemical, and clinical investigations. Our research encompasses multiple disciplines including basic, translational, and clinical sciences and joins faculty with diverse expertise in lung biology, immunology, microbiology, molecular genetics, chemistry, computational biology, infectious diseases, pulmonary and critical care medicine to provide broad opportunities in training, education, and research.